![]() ![]() ![]() Drawing on wide-ranging references from music, literature, film, architecture and pop culture, the artist creates densely layered environments with the ability to transport viewers into alternative narrative, temporal and psychological dimensions.įor Alienarium 5, Gonzalez-Foerster has collaborated with writer and philosopher Paul B. ![]() Engaging with the exhibition as a medium, Gonzalez-Foerster’s spatial inventions and investigations probe the notion of display, as well as how an image or scene is experienced. Working experimentally, she has collaborated with Serpentine on numerous interdisciplinary projects. Gonzalez-Foerster is a leading artist of her generation. Conceived site-specifically for Serpentine, the exhibition will feature almost entirely new work that engages both the gallery’s internal and external space. Dominique Gonzalez-Foerster’s first major institutional solo show in the UK since TH.2058 at Tate Modern’s Turbine Hall in 2008, the exhibition is a culmination of her decades-long interest in science fiction and continued research into deep space and alien life. The files also note that the number of UFO reports doubled after the release of Steven Spielberg's film Close Encounters of the Third Kind in 1977.“This sprawling galactic installation is a mash-up of political, literary and pop culture sci-fi references with a diorama including everyone from Yayoi Kusama to Diana, Princess of Wales.” – The GuardianĪlienarium 5 is a speculative environment that invites us to imagine possible encounters with extraterrestrials. In 1982, customers of The Walnut Tree pub near Tunbridge Wells in south-west England reported seeing red and green flashing lights in the sky.īut when quizzed where exactly they had spotted the strange lights they pointed in the direction of the busy London Gatwick airport. "It certainly has no evidence that alien spacecraft have landed on this planet," the memo concluded. ![]() "The Ministry of Defence does not deny that there are strange things to see in the sky," but the note goes on to say that plausible explanations existed for the phenomenon, including space junk burning up in the atmosphere, unusual cloud formations and meteorological balloons. The eight files in the National Archives, covering the period from 1978 to 1987, were released under legislation governing freedom of information following a request from UFO researchers.īut enthusiasts hoping for evidence that aliens were attempting to land in Britain will be disappointed.Ī ministry memo from 1983 says: "The sole interest of the Ministry of Defence in UFO reports is to establish whether they reveal anything of defence interest (eg intruding aircraft). "Most of the UFO sightings here are probably misidentifications of aircraft lights and meteors, but some are more difficult to explain, and include UFOs seen by police officers and pilots, and cases where UFOs have been tracked on radar." Nick Pope, who was responsible for investigating the sightings at the ministry, said: "While there's no evidence of little green men in these files, they should be of immense interest to sceptics and believers. They show that the Ministry of Defence was less worried about the possibility of visitors from outer space than in checking that Unidentified Flying Objects were not in reality evidence of covert spying missions mounted by other countries. The British Government recorded reports of alien spacecraft flying over Liverpool and a UFO hovering over Waterloo Bridge in London, it was revealed in declassified files released overnight.įiles have been opened for the first time detailing hundreds of sightings of unexplained objects in the skies over Britain. ![]()
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![]() If you browse through Toribash forums or through toribash ingame you may come acrose people in certain clans. aside from ingame Toribash has a close knit community on forums, you can find marketing, art, and mods, on the main page along with various events. aikido or an aikido variant known as aikido big dojo are most favorite among the toribash community, aikido and aikido big dojo usually result in fun grappel warfare that is not usually possible in real life making it all the more fun to play. TORIBASH HEAD MODSToribash comes with a variety of mods when loaded, some including aikido, judo, or ninjitsu. you also are given use of hands which can be put into a grabbing state or a non-grabbing state. Toribash is a game where the player must control each joint of the player or "tori" this leads to unique moves that are player specific! Your Tori has a total of 20 joints, each can be moved by either extending, contracting, holding, or relaxing. I could keep going on, but I think I have said enough. (By the way, top left is uke, top right is tori.) There's a chat in the corner, the number of frames is clearly shown in big font at the top of the screen, and either top corner shows each player's score, and their name. It's freeplay, but each player controls either uke or tori and their customizations apply to the character they control. Sparring mods, parkour mods, silly mods, mods pertaining to a specific type of martial arts, etc. There's even millions of mods that change up the play of the game. And they still add more objects to the game, like the more recent hair. The amount of colors and objects to buy using toribash's internal currency, allows for limitless combinations, considering textures, joints, blood, names, trails, etc. The customization on this game is amazing. How many fighting games, no, how many games have allowed you to change your character's movement animation without going into the game files? The joint system allows for some amazing moves and gameplay to be done, and it's also an amazing idea. It's one of the only fighting games that really puts an emphasis on learning and making yourself better. It's one of the few games I have seen that has taken an idea, and perfectly execute it. ![]() ![]() The figures and tables below shows how water enthalpy and entropy changes with temperature (☌ and ☏) at water saturation pressure (which for practicle use, gives the same result as atmospheric pressure at temperatures < 100 ☌ (212☏)). Current Topics in Medicinal Chemistry Special FBDD.Follow the links for definitions of the terms specific enthalpy and entropy.If you have the resources, it may be worthwhile characterizing the thermodynamic profiles of your fragment hits, and – perhaps – looking more closely at those that show enthalpically-driven binding. ![]() Obtaining thermodynamic parameters for small-molecule protein interactions has historically been challenging, but in recent years miniaturization and improvements in technology have brought ITC into more non-specialist labs. Compound 19 shows a highly favorable binding enthalpy, and is the most potent and ligand-efficient of any of the three elaborated molecules. However, this was a relatively modest boost for the more entropic compound 3 to compound 20, but considerably larger for the enthaplically-driven compound 2 to compound 19. In compound 3, the fluorine points towards the hydrophobic wall of the protein.Īdding a 4-benzylamide substituent onto each of these molecules led to improvements in activity. Interestingly, the structure of compound 2 shows a specific interaction between the fluorine atom and a main-chain NH of the protein. The researchers determined high-resolution crystal structures for all three of these molecules bound to hCA II. In contrast, compound 3 has a similar enthalpy of binding as compound 1 but increased entropy. However, a look at the thermodynamic parameters reveals that the affinity of compound 2 is driven by a sizable improvement in enthalpic binding, partially offset by lowered entropy. If you were choosing between these fragments solely on the basis of affinity or ligand efficiency, it would be reasonable to choose compound 3, and in fact a search of the literature turned up 15 carbonic anhydrase inhibitors that contained the 3-fluorobenzenesulfonamide substructure and none that contained the 2-flurobenzenesulfonamide substructure. In contrast, adding a fluorine to the 3-position (compound 3) improves the potency by seven-fold and also improves the ligand efficiency. Adding a fluorine group to the 2-position of benzenesulfonamide (compound 2) improves the potency almost three-fold but lowers the ligand efficiency. Benzenesulfonamide (compound 1, below) is a known binder, and the researchers studied the thermodynamics of 20 derivatives of this molecule using isothermal titration calorimetry (ITC), taking care to generate high-quality binding data. ![]() The researchers used human carbonic anhydrase (hCA II), a venerable work-horse of biophysical studies. In a new paper in ChemMedChem, Andrew Scott and colleagues at Pfizer show how fragments that owe more of their binding affinity to enthalpy make better starting points for optimization than do fragments whose binding is more entropic, even if the entropic fragment is more potent. Optimizing enthalpy is usually more difficult than optimizing entropy: engineering a polar interaction requires more precision than adding a bit of grease. On a (very) simplistic level, enthalpic binding comes via specific molecular interactions, such as hydrogen bonds, while entropic binding results from nonspecific hydrophobic interactions. Affinity, or binding energy, can be dissected into two components: enthalpy and entropy. The earliest stages of lead discovery usually focus on obtaining a molecule with decent affinity for a given target. ![]() ![]() ![]() ![]() However, we are still far from understanding the physiological and molecular bases of this phenomenon.Īuricularia auricula-judae melanin belongs to the 3,4-dihydroxyphenylalanine (DOPA) melanin, and it was initially determined to be pheomelanin by Sephadex G-100 column chromatography, which is a complex polyphenolic compound ( Zou et al., 2013). auricula-judae fruiting bodies turned to yellow after the mycelium was frozen. auricula-judae ( Gao, 2012), but the fruit color has been greatly affected, which is the most important indicator to estimate the food quality of A. Freezing treatment can significantly improve the yield and quality of A. #DEFINE AURICULA FULL#auricula-judae in the winter, the cultivation species full of mycelium are put outdoors for quick-freezing, followed by waiting for ear emergence in the spring. The freezing pretreatment of the mycelium is a common method and key step of bagging cultivation in northern China, and when producing cultivation species of A. Compared with wood cultivation, bagging cultivation ( Supplementary Figure 1) is more widely used because of the lower expenses, including wood resources and economic investment, as well as the avoidance of pesticides and viruses ( Lv, 2008). auricula-judae is mainly cultivated by two different methods, wood cultivation and bagging cultivation ( Lv, 2008). In 2012, its production in Heilongjiang was more than 3,000,000 tons, with an output value of more than 20 billion yuan ( Liu and Hu, 2018). auricula-judae, its harvesting method has gradually evolved from wild collection to artificial cultivation.Īuricularia auricula-judae is widely cultivated in China, and northern China was the major cultivation area ( Li et al., 2019). ![]() With the improvement of the nutritional and medicinal values of A. auricula-judae has been cultivated on a large scale in northern China, with a yield that ranked fourth in the world ( Zhang et al., 2007). auricula-judae is geographically distributed in Asia, Europe, North America, and other places throughout temperate and subtropical regions ( Akpaja et al., 2005). auricula-judae is also known for its medicinal properties, such as its antitumor, detoxification, anticoagulant, hypoglycemic, and cholesterol-lowering effects ( Nguyen et al., 2012). auricula-judae.Īuricularia auricula-judae is an edible nutrient-rich mushroom, which is an important food resource in Asia due to it being rich in proteins, microelements, vitamins, and carbohydrates as well as its low fat content ( Luo et al., 2009). ![]() This work will be expected to provide valuable information on the physiological and molecular mechanisms of freezing treatment on the color quality of A. The proteomic analysis showed that proteins involved in glycolysis/gluconeogenesis, tyrosine metabolism, ribosome, and arginine biosynthesis might contribute to the color differences in the A. Our findings showed that a longer freezing treatment causes a lighter color of A. auricula-judae was analyzed by physiological assays and a proteomics approach. In the present study, the synthesis of melanin in A. auricula-judae, but the mechanism of the effects of freezing treatment on melanin accumulation remains unknown. It is known that environment stimuli will affect the production of melanin by A. 2College of Life and Environmental Science, Wenzhou University, Wenzhou, ChinaĪuricularia auricula-judae is an edible nutrient-rich mushroom, which is a traditional medicinal resource in China.1Key Laboratory of Saline-alkali Vegetation Ecology Restoration, Ministry of Education, College of Life Sciences, Northeast Forestry University, Harbin, China.Jiawen Li 1†, Ziwei Li 1†, Tong Zhao 1, Xiufeng Yan 2* and Qiuying Pang 1* ![]() |
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